Neuroscience Meeting

  Lunteren, The Netherlands • 9-10 June 2016  



  • Thursday, 9 June

    Friday, 10 June

    09:00 Registration

    09:50 Plenary Session: Opening & Hersenstichting Lecture

    11:00 Coffee & Tea

    11:30 Parallel Sessions A

    • Hypothalamic neuron-glial mal-interactions in metabolic disorders: new players and novel therapy approaches a GliaNED session
    • Human induced pluripotent stem cell modeling of brain diseases
    • Effort, performance and fatigue: the role of motivation in health and disease
    • Functional magnetic resonance imaging (fMRI): brain pathologies and the impact of novel treatment modalities
    • Stress-related mental disorders: is the marriage between basic research and clinical application a happy one?

    13:00 Lunch

    14:00 Parallel Sessions B

    • Microglial cells in the healthy and diseased brain a GliaNED session
    • microRNAs as therapeutic targets in brain pathologies. How far are we from the patient’s bed?
    • Memory traces unraveled: spatial and temporal dissection of memory circuits
    • Ion channels of the nervous system in health and disease
    • Bridging clinical and fundamental research on neurodevelopmental disorders

    15:30 Drinks

    16:00 Parallel Sessions: Discussion Groups

    • Public-Private Partnerships
    • Translational Neuroscience Discussion Session

    17:00 Drinks

    18:00 Dinner

    19:30 Plenary Session

    20:30 Posters

    22:00 Social

    09:00 Parallel Sessions C

    • Human induced pluripotent stem cell-derived astrocyte models for neurological disorders a GliaNED session
    • The role of lipid metabolism on brain functioning in health and disease
    • Epigenetic dysregulation in aging and Alzheimer’s disease
    • Using non-human species to model human emotions and high cognitive functions
    • The parahippocampal region: from development to information processing
    • New Frontiers in autism research

    10:30 Coffee & Tea

    11:00 Parallel Sessions D

    • Effects of perinatal environment on neuroinflammation throughout life a GliaNED session
    • BDNF signalling during development, stress and neurodegeneration
    • Go to the start, ready...Go! Novel insights into mechanisms of attention
    • The role of social evaluation in development and psychiatric disease
    • Phosphodiesterases in the CNS: mechanistic windows of opportunities
    • Neuroimaging in people at risk for psychosis: structure, function and chemistry

    12:30 Posters & Lunch

    14:00 Parallel Sessions E

    • The role of glia in various diseases a GliaNED session
    • Active sensing
    • It’s all about the money: alterations in the reward system across disorders
    • In vitro experiments in acute human brain slices: the novel structural and functional properties of adult human neurons
    • Early life exposure to drug and nutrition: effects on brain and behavior

    15:30 Drinks

    16:00 Plenary Session

    • Young Talent Prize
    • Keynote Lecture

    17:30 Closure DN 2016

    • Thursday .::. 9 June

      09:00 Registration

      09:50 Plenary Session: Opening & Hersenstichting Lecture
      Session 1: Hersenstichting Lecture[Europa]
      Chair: Maria Carrillo (Amsterdam)

      Frans de Waal (Atlanta, GA, USA) Cognitive continuity: a kingdom full of special mental capacities (60')

      11:00 Coffee & Tea

      11:30 Parallel Sessions A
      Session 2: Hypothalamic neuron-glial mal-interactions in metabolic disorders: new players and novel therapy approaches a GliaNED session[Room 5]
      Chairs: Andries Kalsbeek & Chun-Xia Yi (Amsterdam)

      Christoffer Clemmensen (Munich, Germany) Hypothalamic neuron-glial mal-interaction in metabolic disorders: new players and novel therapy approaches (30')
      Susanne La Fleur (Amsterdam) The interaction between nutrition and the brain and its consequences for energy metabolism (15')
      Yuanqing Gao (Munich, Germany) Dietary sugar triggers hypothalamic inflammatory response via advanced glycation end-products (15')
      Kathy de Git (Utrecht) Individual variation in leptin sensitivity (15')
      Evita Belegri (Amsterdam) Nutrient composition and energy status influence the hypothalamic inflammatory response to diet-induced obesity (15')

      Session 3: Human induced pluripotent stem cell modeling of brain diseases[Europa]
      Chairs: Femke de Vrij & Shashini Munshi (Rotterdam)

      Lill Eva Johansen (Utrecht) iPSC-derived neurons as a novel model for studying inflammatory neuropathies (15')
      Aishwarya Geeyarpuram Nadadhur (Amsterdam) Neuronal and glial co-cultures from TSC iPSCs to study in vitro phenotypic defects (15')
      Gerrald Lodewijk (Amsterdam) Human stem cell-derived brain organoids to model development and disease of the human brain (15')
      Shashini Munshi (Rotterdam) Gene editing in human induced pluripotent stem cells using CRISPR/Cas9 (15')
      Femke de Vrij (Rotterdam) Using induced pluripotent stem cells to model familial schizophrenia (30')

      Session 4: Effort, performance and fatigue: the role of motivation in health and disease[Vide]
      Chairs: Stijn Massar (Singapore, Singapore) & Dimitri van der Linden (Rotterdam)

      Masud Husain (Oxford, United Kingdom) The neurobiology of apathy and motivation in humans (30')
      Dimitri van der Linden (Rotterdam) The nature and psychophysiology of mental fatigue (15')
      Jesper Hopstaken (Rotterdam) Conquering fatigue: insights from the locus-coeruleus norepinephrine system (15')
      Stijn Massar (Singapore, Singapore) Effort-based decision making and motivation during rested and sleep deprived states (15')
      Marieke van der Schaaf (Nijmegen) Biased performance monitoring of physical effort in chronic fatigue (15')

      Session 5: Functional magnetic resonance imaging (fMRI): brain pathologies and the impact of novel treatment modalities[Room 3]
      Chairs: Bert Joosten & Koen Meuwissen (Maastricht)

      Patrick Stroman (Kingston, ON, Canada) Progress toward assessments of individual pain mechanisms by means of functional MRI of the brainstem and spinal cord (30')
      Kâmil Uludağ (Maastricht) Physiological and physical basis of functional MRI – Implications for reproducibility (15')
      Gerbrich van den Bosch (Rotterdam) Long term consequences of neonatal pain and pain treatment; an fMRI study (15')
      Theresia Roelofs (Utrecht) DREADD-phMRI as a novel approach to map activation of neuronal networks (15')
      Koen Meuwissen (Maastricht) Analysis of supraspinal mechanisms underlying conventional and high-frequency burst spinal cord stimulation, by means of functional magnetic resonance imaging (15')

      Session 6: Stress-related mental disorders: is the marriage between basic research and clinical application a happy one?[Room 13]
      Chairs: Marloes Henckens (Nijmegen) & Marian Joëls (Utrecht)

      Aline Desmedt (Bordeaux, France) Distinguishing “pathological” from “normal” fear memory:
      a prerequisite for studying PTSD-related memory in animals (30')

      Harm Krugers (Amsterdam) Early life adversity moderates emotional memory processing (15')
      Vanessa van Ast (Amsterdam) Out of context: impaired memory integration as vulnerability for PTSD (15')
      Eric Vermetten (Utrecht) Can we achieve precision in PTSD studies? (15')
      Rianne de Kleine (Nijmegen) D-cycloserine augmentation of exposure therapy for PTSD (15')

      13:00 Lunch

      14:00 Parallel Sessions B
      Session 7: Microglial cells in the healthy and diseased brain a GliaNED session[Room 5]
      Chairs: Anne-Marie van Dam (Amsterdam) & Ilia Vainchtein (Groningen)

      Marco Prinz (Freiburg, Germany) Microglia: fate and function (30')
      Nynke Oosterhof (Rotterdam) Functional genetics of microglial activation (15')
      Marloes Hagens (Amsterdam) Positron Emission Tomography: microglial imaging in neurological disease (15')
      Bart Eggen (Groningen) Expression profiling of human post-mortem microglia (30')

      Session 8: microRNAs as therapeutic targets in brain pathologies. How far are we from the patient’s bed?[Vide]
      Chairs: Carlos Fitzsimons (Amsterdam) & David Henshall (Dublin, Ireland)

      David Henshall (Dublin, Ireland) Targeting microRNA for the treatment of epilepsy: how soon to the clinic? (30')
      Eleonora Aronica (Amsterdam) microRNAs: key regulators of neuroinflammation (15')
      Pascal Bielefeld (Amsterdam) Regulation of adult hippocampal neurogenesis after Kainic Acid-induced Status Epilepticus by microRNAs: a possible new therapeutic target? (15')
      Danijela Koppers (Amsterdam) Post-transcriptional processing and modifications define small RNA sorting into extracellular vesicles (15')
      Daniel van den Hove (Maastricht) The miR-137 VNTR and cognitive decline in mild cognitive impairment (MCI) (15')

      Session 9: Memory traces unraveled: spatial and temporal dissection of memory circuits[Room 13]
      Chairs: Michel van den Oever (Amsterdam) & Priyanka Rao (Rotterdam)

      Karim Nader (Montreal, QC, Canada) The recovery from amnesia is fools gold. Specific impairments in synaptic consolidation, reconsolidation, and LTM maintanence lead to memory erasure (30')
      Priyanka Rao (Rotterdam) What memories Arc made of (15')
      Francesco Battaglia (Nijmegen) Hippocampal/cortical interactions during sleep (15')
      Mariana Matos (Amsterdam) Early formation of a cortical fear engram is required for memory persistence (15')
      Michelle de Haan (Amsterdam) Fear-potentiated startle responding in concurrent fMRI research on human fear learning: the effect of acoustic startle probes (15')

      Session 10: Ion channels of the nervous system in health and disease[Europa]
      Chairs: Armagan Kocer & Dineke Verbeek (Groningen)

      Yasushi Okamura (Osaka, Japan) Principle and biodiversity of voltage sensor domain proteins (30')
      Chris De Zeeuw (Rotterdam) Role of GluR2/3 AMPA receptors in cerebellar learning (15')
      Maarten Kole (Utrecht) Kv7.2 (KCNQ2) channels in pre-myelinated axons and their role in early-onset epileptogenesis (15')
      Dirk Schubert (Nijmegen) Missing the moment: impaired switch to mature chloride transporter and GABAA subunit expression in the juvenile cortex following excessive serotonin levels during brain development (15')
      Armagan Kocer (Groningen) Voltage-gated potassium channel Kv4.3 in cells and artificial cell models (15')

      Session 11: Bridging clinical and fundamental research on neurodevelopmental disorders[Room 3]
      Chairs: Sharon Kolk & Tjitske Kleefstra (Nijmegen)

      Tjitske Kleefstra (Nijmegen) Clinical genetic aspects in neurodevelopmental disorders and the bridge to fundamental insights: haploinsufficiency of SIN3A as an example (15')
      Sharon Kolk (Nijmegen) Gene loss-of-functions, corticogenesis and neurodevelopmental disorders (15')
      Lisa Hinz (Amsterdam) Developmental differences in iPSC-derived neural cell types from Rett syndrome patients (15')
      Jasper Visser (Nijmegen) From molecule to man - and back. Lessons from Lesch-Nyhan disease (15')
      Ype Elgersma (Rotterdam) Neurodevelopmental disorders: from basic mechanisms to clinical trials (30')

      15:30 Drinks

      16:00 Parallel Sessions: Discussion Groups
      Session 12: Public-Private Partnerships
      Session 13: Translational Neuroscience Discussion Session[Europa]

      17:00 Drinks

      18:00 Dinner

      19:30 Plenary Session
      Session 14: Top Papers & Ph.D. Thesis Prizes[Europa]

      20:30 Posters
      Session 15: Poster session 1[Asia/Africa]

      22:00 Social


    • Friday .::. 10 June

      09:00 Parallel Sessions C
      Session 16: Human induced pluripotent stem cell-derived astrocyte models for neurological disorders a GliaNED session[America]
      Chairs: Vivi Heine (Amsterdam) & Monica Frega (Nijmegen)

      Laurent Roybon (Lund, Sweden) Human induced pluripotent stem cell-derived glia: gaining better insights into neurological disorders (30')
      Monica Frega (Nijmegen) How astrocytes affect neuronal circuitry in neurodevelopmental disorders (15')
      Stephanie Hoekstra (Amsterdam) The study of schizophrenia patient iPSC-derived astrocytes (15')
      Bas Lendemeijer (Rotterdam) Rapid specification of human pluripotent stem cell derived neural progenitors to transplantable astrocytes (15')
      Prisca Leferink (Amsterdam) Stem cell derived glial cells for disease modeling and transplantation therapy for Vanishing White Matter disease (15')

      Session 17: The role of lipid metabolism on brain functioning in health and disease[Room 13]
      Chairs: Kit-Yi Yam & Brenda Penninx (Amsterdam)

      Agnes Nadjar (Bordeaux, France) Polyunsaturated fatty acids modulate brain response to neuroinflammation (30')
      Aldo Grefhorst (Rotterdam) Regulation of triglyceride metabolism of liver and brown adipose tissue by stress hormones (15')
      Brenda Penninx (Amsterdam) Depression and obesity: understanding mechanisms connecting the two (15')
      Kit-Yi Yam (Amsterdam) Reduced dietary omega-6 to omega-3 fatty acid ratio in early life protects against early-life stress induced cognitive impairments and restores levels of neurogenesis (15')
      Mark Verheijen (Amsterdam) Oligodendroglial myelination requires astrocyte-derived lipids (15')

      Session 18: Epigenetic dysregulation in aging and Alzheimer’s disease[Room 3]
      Chairs: Daniel van den Hove & Artemis Iatrou (Maastricht)

      Katie Lunnon (Exeter, United Kingdom) Epigenetic profiling in Alzheimer's disease (30')
      Carlos Fitzsimons (Amsterdam) Glucocorticoid hormones preserve a population of adult hippocampal neural stem cells in the aging brain (15')
      Monique van der Wijst (Groningen) Functional relevance of mitochondrial DNA methylation (15')
      Daniel van den Hove (Maastricht) Alzheimer’s disease-specific genome-wide DNA methylation and hydroxymethylation patterns in the middle temporal gyrus (15')
      Artemis Iatrou (Maastricht) Differential miR-137 expression and methylation in Alzheimer’s disease (15')

      Session 19: Using non-human species to model human emotions and high cognitive functions[Vide]
      Chairs: Maria Carrillo & Ingo Willuhn (Amsterdam)

      Cristina Marquez (Alicante, Spain) To help or not to help? Mechanisms of prosocial choice in rats (30')
      Pieter Goltstein (Martinsried, Germany) Visual category learning as a paradigm for studying associative memory in mice (15')
      Evelien Schut (Nijmegen) Long-term imaging of neural ensembles in a mouse model of intellectual disability (15')
      Jeroen Verharen (Utrecht) Ascending midbrain projection-specific mechanisms underlying altered decision-making during hyperdopaminergic states (15')
      Maria Carrillo (Amsterdam) How valid is the use of rodents as a non-human model to investigate the neural mechanisms of empathy? (15')

      Session 20: The parahippocampal region: from development to information processing[Room 5]
      Chairs: Natalie Cappaert & Janske Willems (Amsterdam)

      Rhiannon Meredith (Amsterdam) Pacemakers and waves: early development of rodent medial entorhinal cortex (15')
      Dietmar Schmitz (Berlin, Germany) Differential embedding of hippocampal output neurons during high-frequency oscillations (30')
      Janske Willems (Amsterdam) Parvalbumin positive interneurons mediate a strong inhibitory control of synaptic input on principal neurons in the perirhinal-entorhinal network (15')
      Jeroen Bos (Amsterdam) Sustained firing patterns in rat perirhinal cortex chunk large segments of spatial trajectories (15')
      Tobias Navarro Schroeder (Nijmegen) Reduced grid-cell-like representations in adults at genetic risk for Alzheimer’s disease (15')

      Session 21: New Frontiers in autism research[Europa]
      Chairs: Louk Vanderschuren (Utrecht) & Martien Kas (Groningen)

      Will Spooren (Basel, Switzerland) EU-AIMS: a Public-Private Consortium to boost Autism Research in Europe (30')
      Jeffrey Glennon (Nijmegen) Translational neuroscience in autism: Cohort design, measures and rationale for the EU-AIMS Longitudinal European Autism Project (EU-AIMS LEAP) (15')
      Barbara Biemans (Basel, Switzerland) The Roche research network: a unique approach to discovering treatments for a complex disorder (15')
      Marijke Achterberg (Utrecht) A two-hit model for social dysfunction in the rat (15')
      Remco Molenhuis (Utrecht) How to measure restricted repetitive behaviors and model autism’s genetic diversity in mice? (15')

      10:30 Coffee & Tea

      11:00 Parallel Sessions D
      Session 22: Effects of perinatal environment on neuroinflammation throughout life a GliaNED session[America]
      Chairs: Aniko Korosi (Amsterdam) & Agnes Nadjar (Bordeaux, France)

      Agnes Nadjar (Bordeaux, France) Perinatal omega-3 deficiency alters microglia-neuron interactions during brain maturation (30')
      Sara Schaafsma (Utrecht) Sex-specific vulnerability to prenatal stress. Are microglia involved? (20')
      Lianne Hoeijmakers (Amsterdam) Early-life stress modulates microglia function and Alzheimer’s disease neuropathology in APPswe/PS1dE9 mice (20')
      Caroline de Theije (Utrecht) White matter injury of prematurity: from pathogenesis to novel treatments (20')

      Session 23: BDNF signalling during development, stress and neurodegeneration[Europa]
      Chairs: Gunter Kenis (Maastricht) & Judith Homberg (Nijmegen)

      Laurence Lanfumey (Paris, France) Neurotrophic effects of antidepressants (30')
      Judith Homberg (Nijmegen) BDNF-Serotonin interaction during development and early-life stress (15')
      Marion Lévy (Maastricht) Cognitive effects of TrkB agonists in APP/PS1 mice (15')
      Tim Vanmierlo (Hasselt, Belgium) Early-postnatal iron deficiency reduces synaptic plasticity in the hippocampus of pigs (15')
      Gunter Kenis (Maastricht) Peripheral BDNF expression in relation to depressive symptoms during ECT treatment (15')

      Session 24: Go to the start, ready...Go! Novel insights into mechanisms of attention[Room 3]
      Chairs: Tommy Pattij & Huib Mansvelder (Amsterdam)

      Bita Moghaddam (Pittsburgh, PA, USA) Ventral tegmental dopamine neurons and attention (30')
      Antonio Luchicchi (Amsterdam) Attention requires distinct temporal activation of the dorsal and ventral medial prefrontal cortex (15')
      Matthew Self (Amsterdam) The role of attention in grouping the visual scene (15')
      Barrie Klein (Utrecht) Spatial attention modulates representations of visual space in humans (15')
      Matthias Ekman (Nijmegen) Automatic spread of the attentional field from a spatial cue to an underlying object in primary visual cortex (15')

      Session 25: The role of social evaluation in development and psychiatric disease[Room 5]
      Chairs: Frederik van der Veen (Rotterdam) & Michelle Achterberg (Leiden)

      Geert-Jan Will (London, United Kingdom) Neural and computational processes underlying dynamic fluctuations in self-esteem (30')
      Melle van der Molen (Leiden) Social evaluative feedback processing in the brain: midfrontal theta power in response to unexpected peer rejection (15')
      Michelle Achterberg (Leiden) The neural correlates of social evaluation and aggression in children and adults (15')
      Charlotte van Schie (Leiden) Dealing with interpersonal evaluations: affective and neural responses in borderline personality disorder (15')
      Frederik van der Veen (Rotterdam) The impact of social rejection on depressed patients and depressive symptoms in healthy volunteers (15')

      Session 26: Phosphodiesterases in the CNS: mechanistic windows of opportunities[Vide]
      Chairs: Jos Prickaerts (Maastricht) & Robbert Havekes (Groningen)

      Susana Neves (New York, NY, USA) PDE diversity in dopamine signaling (30')
      Tony West (Chicago, IL, USA) Targeting cyclic nucleotide phosphodiesterases for the treatment of movement disorders (30')
      Pim Heckman (Maastricht) Phosphodiesterase inhibition and dopaminergic modulation of impulsivity (15')
      Robbert Havekes (Groningen) The tired hippocampus, the role of hippocampal PDE4 signaling in the cognitive deficits associated with sleep deprivation (15')

      Session 27: Neuroimaging in people at risk for psychosis: structure, function and chemistry[Room 13]
      Chairs: Matthijs Bossong (Utrecht) & Paul Allen (London, United Kingdom)

      Paul Allen (London, United Kingdom) The neurobiology of psychosis onset: what have we learned from human brain imaging studies? (30')
      Bart Peters (Amsterdam) Imaging of white matter development in the early stages of psychosis (15')
      Edith Liemburg (Groningen) Lower prefrontal activation during emotion regulation in subjects at ultrahigh risk for psychosis: an fMRI-study (15')
      Oswald Bloemen (Maastricht) Striatal dopamine in people at ultra high risk for psychosis (15')
      Erika van Hell (Utrecht) PSYSCAN: a multi-centre study towards predicting the development, course and outcome of psychosis (15')

      12:30 Posters & Lunch
      Session 28: Poster session 2[Asia/Africa]

      14:00 Parallel Sessions E
      Session 29: The role of glia in various diseases a GliaNED session[America]
      Chairs: Wytse Wadman & Rogier Min (Amsterdam)

      Christian Steinhäuser (Bonn, Germany) Cytokine-induced uncoupling of hippocampal astrocytes as a cause of human temporal lobe epilepsy (30')
      Eelke Brouwers (Amsterdam) Increased neuronal excitability caused by dysfunctioning astrocyte ion and water homeostasis (15')
      Lana Osborn (Amsterdam) Reactive astrocytes in an Alzheimer mouse model change Kir4.1 expression and function (15')
      Rogier Min (Amsterdam) The role of glial versus neuronal cannabinoid receptors in developmental plasticity of the visual cortex (15')
      Laura Kuil (Rotterdam) Towards an inducible in vivo excitotoxicity model (15')

      Session 30: Active sensing[Europa]
      Chairs: Tansu Celikel & Rémi Proville (Nijmegen)

      Carl Petersen (Lausanne, Switzerland) Cortical control of whisker movement (30')
      Elie Wandersman (Paris, France) Tactile object localization by whisker touch (15')
      Vincenzo Romano (Rotterdam) Coherent activity in barrel, motor and cerebellar cortex during well­timed active exploration (15')
      Hemanth Mohan (Amsterdam) The neuronal code in association cortex during active sensing (15')
      Alice Tomassini (Nijmegen) Visual rhythms synchronize with voluntary hand movements (15')

      Session 31: It’s all about the money: alterations in the reward system across disorders[Vide]
      Chairs: Lisette Charbonnier & Matthijs Vink (Utrecht)

      Jean-Claude Dreher (Lyon, France) Reward processing in various neuropsychiatric disorders: insights from fMRI and intracranial recordings (30')
      Sabine Spijker (Amsterdam) Incubation of cocaine memories (15')
      Ruth van Holst (Amsterdam) Abnormal dopamine synthesis capacity in gambling addiction (15')
      Matthijs Vink (Utrecht) Development of the frontostriatal reward network in adolescents at risk for psychosis (15')
      Lisette Charbonnier (Utrecht) Hunger for more: lack of striatal downregulation after satiation during monetary reward anticipation in overweight individuals (15')

      Session 32: In vitro experiments in acute human brain slices: the novel structural and functional properties of adult human neurons[Room 3]
      Chairs: Christiaan de Kock (Amsterdam) & Maarten Kole (Utrecht)

      Christiaan de Kock (Amsterdam) Human neurons are structurally and functionally very different compared to mouse and monkey neurons (15')
      Joshua Obermayer (Amsterdam) Active signal propagation in dendrites of human neurons (15')
      Natalia Goriounova (Amsterdam) Linking human pyramidal neurons to cognition (15')
      Maarten Kole (Utrecht) Initiation and amplification of the action potential in human axons and dendrites (15')
      Mariana Vargas-Caballero (Southampton, United Kingdom) Age dependent changes of synaptic composition in human cortical synapses (30')

      Session 33: Early life exposure to drug and nutrition: effects on brain and behavior[Room 5]
      Chairs: Jocelien Olivier (Groningen) & Richard Dyck (Calgary, Canada)

      Richard Dyck (Calgary, AB, Canada) Long-term effects of perinatal fluoxetine on the brain and behavior (30')
      Danielle Houwing (Groningen) Effects of maternal depression and antidepressant treatment during pregnancy on social behavior in the offspring (20')
      Lisa van de Wijer (Nijmegen) The effects of perinatal administration of the HIV-drug efavirenz on neurodevelopment and early-life behavior (20')
      Åsa Edvinsson (Uppsala, Sweden) Antidepressant treatment and placental function (20')

      15:30 Drinks

      16:00 Plenary Session
      Session 34: Young Talent Prize[Europa]
      Session 35: Keynote Lecture[Europa]
      Karim Nader (Montreal, QC, Canada) Targeting memories as a new therapeutic approach to psychopathologies (60')

      17:30 Closure DN 2016


    • Thursday .::. 9 June

      P1.1  The effect of the circadian glucocorticoid rhythm on neuroplasticity of the amygdala and hippocampus
      Marie Colombe Agahozo (Utrecht)

      P1.2  Fear elicits changes in synaptic activity by activating AMPA-receptor subunit GluA3
      Eva Albers (Amsterdam)

      P1.3  Development of a high throughput-screening assay for astrogliosis in vitro
      Aina Badia Soteras (Amsterdam)

      P1.4  Tyrobp mutant zebrafish as a model for Nasu Hakola disease
      Jan Willem Bek (Rotterdam)

      P1.5  Differences in functional connectivity between offspring with high vs low risk for bipolar disorder
      Julia Binnewies (Utrecht)

      P1.6  The basal interstitial nucleus: a unique inhibitory afferent input to the cerebellar flocculus
      François Blot (Rotterdam)

      P1.7  Mineralocorticoid receptor function and early life stress: mapping HPA axis reactivity
      Valeria Bonapersona (Utrecht)

      P1.8  The effects of early life stress and genetic variances in serotonin transporter on social behavior and ethanol consumption in rats
      Bryan Bonsing (Groningen)

      P1.9  Pitx3-ITC: a new genetic strategy for dissecting dopaminergic pathway development
      Sara Brignani (Utrecht)

      P1.10  Increased expression of (immuno) proteasome subunits in experimental and human temporal lobe epilepsy
      Diede Broekaart (Amsterdam)

      P1.11  Prosocial behavior in rats in response to a conspecific’s distress
      Rune Bruls (Amsterdam)

      P1.12  Neuronal activity induced changes of energy metabolites in the mouse suprachiasmatic nucleus
      Renate Buijink (Leiden)

      P1.13  Impulsive decision-making with the lights ON: optically inhibiting frontal glutamatergic transmission during choice behaviour alters delayed reward preference
      Madison Carr (Amsterdam)

      P1.14  In vitro effect of G-protein coupled receptor GPR158 on contact- mediated synapse formation and morphology in hippocampal neurons
      Demirhan Cetereisi (Amsterdam)

      P1.15  Doublecortin-like: a novel neuroplasticity protein involved in energy homeostasis [*** WITHDRAWN ***]
      Claudia Coomans (Leiden)

      P1.16  Aβ selectively targets conductive GluA3-containing synapses
      Carla da Silva Matos (Amsterdam)

      P1.17  Shaping resilience to early life stress: focus on mineralocorticoid receptor effects on social behavior in male and female mice
      Ruth Damsteegt (Utrecht)

      P1.18  Changes in cortical thickness as a result of tinnitus
      Charlotte de Blecourt (Groningen)

      P1.19  The C2B domain of RIM1 increases release probability of primed synaptic vesicles
      Arthur de Jong (Boston, MA, USA)

      P1.21  Cerebrospinal fluid stimulates proliferation of glioma stem cells
      Sophietje de Sonnaville (Utrecht)

      P1.22  Human APOE4-specific effects on cerebral ceramide and fatty acid profiles in mice
      Sandra den Hoedt (Rotterdam)

      P1.23  Effects of early life stress on synaptic plasticity in the developing hippocampus of male and female rats
      Nienke Derks (Utrecht)

      P1.24  Cortical glutamatergic progenitors persist long after closure of the corticogenesis period
      Vanessa Donega (Lyon, France)

      P1.25  Is misleading information integrated into memories through reconsolidation?
      Sascha Duken (Amsterdam)

      P1.26  Synaptic zinc is required for the enhancement of adult hippocampal neurogenesis
      Richard Dyck (Calgary, AB, Canada)

      P1.27  The effect of pulsed radiofrequency treatment applied adjacent to the dorsal root ganglion in an experimental model for chronic neuropathic pain: behavioral assessment
      Glenn Franken (Maastricht)

      P1.28  Early development of medial prefrontal cortex sub-areas
      Lidiane Garcia (Nijmegen)

      P1.29  Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development
      Miguel A. Gonzalez Lozano (Amsterdam)

      P1.30  Emotional contagion for pain in rats from different strains
      Yingying Han (Amsterdam)

      P1.31  The effect of soluble amyloid-beta (Aβ) on synaptic inhibition
      Lotte Herstel (Utrecht)

      P1.32  The effect of cerebellar transcrianial direct current stimulation on vestibular ocular reflex adaptation consolidation
      Marco Heuvelman (Amsterdam)

      P1.33  The effects of activated leptin receptor containing neurons in the LHA and VTA on motivational feeding behaviour in mice
      Anna Hoefnagels (Utrecht)

      P1.34  Canonical correlation analysis on causal maps produced with ‘Momentum’
      Jirrine Hogenaar (Nijmegen)

      P1.35  Dendritic coordination between excitatory and inhibitory plasticity
      Hai Yin Hu (Utrecht)

      P1.36  The effects of a five-week c-mill training in patients with spinocerebellar ataxia
      Karen Huisman (Nijmegen)

      P1.37  The influence of focused attention meditation on oscillatory brain dynamics [*** WITHDRAWN ***]
      Mona Irrmischer (Amsterdam)

      P1.38  Regulation of aberrant adult hippocampal neurogenesis after Kainic Acid-induced Status Epilepticus by microRNAs: gliogenesis and reactive Neural Stem Cells
      Sedef Karayel (Amsterdam)

      P1.39  The functional role of individual alpha frequency in visuospatial attention: neuroenhancement by transcranial alternating current stimulation
      Selma Kemmerer (Maastricht)

      P1.40  The effects of early life stress on social competence and behavioral inhibition. Possibilities for intervention
      Jiska Kentrop (Utrecht)

      P1.41  How obesity may predispose for anxiety: review of the literature and presence of metabolic receptors in the fear circuitry
      Lisa Koorneef (Leiden)

      P1.42  Short-term effects in the affective and cognitive domain of social defeat in mice
      Maija Koskinen (Amsterdam)

      P1.43  Extra-hypothalamic corticotropin releasing factor containing systems in the three hit theory model of depression in mice
      László Ákos Kovács (Pécs, Hungary)

      P1.44  The role of Lmx1B in subset specification of mesodiencephalic dopaminergic neurons
      Pablo Largo Barrientos (Amsterdam)

      P1.45  How are waves of spontaneous activity patterned by inhibition during early postnatal development?
      Alexandra Leighton (Amsterdam)

      P1.46  Characterization of Cacna1a knock-in mice as a model for sudden unexpected death in epilepsy
      Inge Loonen (Leiden)

      P1.47  Oxidative stress and hypomyelination in the development of cognitive symptoms of schizophrenia: studies in the APO-SUS rat model
      Dorien Maas (Nijmegen)

      P1.48  Dissecting the role of parvalbumin interneurons in the medial prefrontal cortex in an attention task in mice: a multiplexed chemogenetic approach
      Elena Marchisella (Amsterdam)

      P1.49  The effect of multisensory stimulation on structural and functional brain connectivity following experimental stroke in rats
      Anu Meerwaldt (Utrecht)

      P1.50  White matter abnormalities in 22q11 deletion syndrome patients showing cognitive decline
      Jasper Nuninga (Utrecht)

      P1.51  Understanding the effects of antagonists on α7 nicotinic acetylcholine receptors
      Dean Paes (Maastricht)

      P1.52  A novel behavioral model of tinnitus in mice
      Alexander Pietrus-Rajman (Groningen)

      P1.53  Extracellular matrix molecules in mesial temporal lobe epilepsy and their modulation by miRNAs in cultured human astrocytes
      Ben Pustjens (Amsterdam)

      P1.54  Decoding dark memories: investigating the role of protein synthesis in memory consolidation during the night
      Frank Raven (Groningen)

      P1.55  Impulsive aggression: could we predict SSRI efficacy with behavioural traits?
      Jonne Rietdijk (Nijmegen)

      P1.56  Differences in resting state functional connectivity patterns of cognitive/emotional and sensorimotor networks in chronic pain
      Linda Romanovska (Maastricht)

      P1.57  The effect of stress on functional connectivity and the role of  structural connectivity in siblings of schizophrenia patients
      Miryea Ruiz (Utrecht)

      P1.58  Towards the molecular basis of ADHD and attention
      Rik Scharn (Nijmegen)

      P1.59  Dissecting the role of actin in inhibitory bouton dynamics
      Lisa Scheefhals (Utrecht)

      P1.60  Characterization of human Kv4.3 channels at the single-channel level, cloning of wild type and mutant Kv4.3 channels in yeast
      Marloes Scholten (Groningen)

      P1.61  The boundaries of fear memory interference: does reconsolidation occur in a novel context?
      Natalie Schroyens (Amsterdam)

      P1.62  Longitudinal methylation changes in the glucocorticoid receptor 1F region and psychopathology after deployment
      Remmelt Schür (Utrecht)

      P1.63  Disentangling the effects of reward value and probability on anticipatory event-related potentials [*** WITHDRAWN ***]
      Iris Schutte (Utrecht)

      P1.64  Functional validation of genetic candidate risk of attention deficit hyperactivity disorder (ADHD) in Drosophila
      Euginia Singgih (Nijmegen)

      P1.65  Second-order eyeblink conditioning in mice
      Ranjit Singh (Rotterdam)

      P1.66  Characterizing primary human microglia: a comparative study with myeloid subsets and culture models
      Marjolein Sneeboer (Utrecht)

      P1.67  Mineralocorticoid receptor expression differentially affects behavioral domains in male and female mice after early life stress
      Kirsten Sparnaaij (Utrecht)

      P1.68  The effects of maternal depression and antidepressant usage during pregnancy on social behaviour in the offspring
      Judith Swart (Groningen)

      P1.69  Spinal cord stimulation frequency and pain relief in the chronic phase of experimental painful diabetic polyneuropathy
      Maarten van Beek (Maastricht)

      P1.70  Effects of impaired synaptic plasticity on hippocampal brain activity in APP/PS1 mice: elucidating the role of GluA3 [*** WITHDRAWN ***]
      Marleen van der Meer (Amsterdam)

      P1.71  On-the-road driving performance of narcolepsy patients receiving long-term sodium oxybate treatment: preliminary results
      Nick van der Sluiszen (Maastricht)

      P1.72  Neuronal Nhe3 (Solute Carrier Family 9, Subfamily A) depletion causes neurodevelopmental and behavioral defects in Drosophila
      Monique van der Voet (Nijmegen)

      P1.73  Blocking α7 nicotinic acetylcholine receptors improves specifically memory acquisition
      Nick van Goethem (Maastricht)

      P1.74  Behavioral and biochemical investigation into the memory enhancing potential of the soluble guanylate cyclase stimulator riociguat
      Britt van Hagen (Maastricht)

      P1.75  Beyond aggression: hyperactivity and social withdrawal in the BALB/cJ mouse
      Sabrina van Heukelum (Nijmegen)

      P1.76  Psychosocial stress and emotion processing in siblings of schizophrenia patients
      Judith van Leeuwen (Utrecht)

      P1.77  Synapse gene ontology and annotation project
      Pim van Nierop (Amsterdam)

      P1.78  Genetic polymorphisms and their association with the prevalence and severity of chronic postsurgical pain – A systematic review
      Roel van Reij (Maastricht)

      P1.79  The role of de novo protein synthesis in the consolidation of spatial memories: different during day and night?
      Lara van Renssen (Groningen)

      P1.80  Foxp2 loss of function mutation affects maturation of striatal D1-MSNs
      Jon-Ruben van Rhijn (Nijmegen)

      P1.81  Expression of inflammation related microRNAs miR21, miR146a and miR155 in tuberous sclerosis complex cortical tubers and their modulation in SEGA cell cultures
      Jackelien van Scheppingen (Amsterdam)

      P1.82  Effects of early life stress on memory and pattern separation; what role plays epigenetics?
      Petra van Soldt (Nijmegen)

      P1.83  Kinesin-binding protein controls microtubule dynamics and cargo trafficking by regulating kinesin motor activity
      Myrrhe van Spronsen (Utrecht)

      P1.84  The NeuroD element is associated with selectivity for mineralocorticoid over glucocorticoid receptor binding in the brain
      Lisa van Weert (Leiden)

      P1.85  Regulation of aberrant adult hippocampal neurogenesis after kainic acid-induced status epilepticus by microRNAs: proliferation, apoptotic selection, and differentiation
      Ruth Willems (Amsterdam)

      P1.86  Perturbed mesoprefrontal dopaminergic targeting contributes to enhanced anxiety and altered social behavior in a mouse model of Parkinson’s disease
      Jolien Witteveen (Nijmegen)

      P1.87  Identification and validation of the molecular pathways underlying Parkinson’s disease
      Helena Xicoy Cortada (Nijmegen)

      P1.88  Effect of early life stress on glutamatergic synaptic transmission in mouse hippocampal dentate gyrus neurons
      Hui Xiong (Amsterdam)

    • Friday .::. 10 June

      P2.1  Effects of chronic early-life stress and early nutrition on hippocampal neurogenic capacity in response to running in female mice
      Maralinde Abbink (Amsterdam)

      P2.2  Novel association of depression with a rare missense variant highly expressed in a unique higher primate glial population
      Maarouf Baghdadi (Rotterdam)

      P2.3  Transcription of UBE3A and protein localization during development in human neurons
      Roberto Ballarino (Rotterdam)

      P2.4  Transient increases in familial fronto-temporal dementia-associated gene transcription after perinatal asphyxia
      Melinda Barkhuizen (Maastricht)

      P2.5  Sex, drugs, and bugs: can the fruit fly be used as a screening platform to discover drugs that affect female sexual receptivity?
      Suzanne Bezema (Groningen)

      P2.6  Disruption of Euchromatin Histone Methyltransferase 1 (Ehmt1) mediated epigenetic regulation reveals dysfunctional neuronal networks in an in vitro model of Kleefstra syndrome
      Elske Bijvank & Britt Mossink (Nijmegen)

      P2.7  Drosophila model of Neurofibromatosis 1 (NF1) as a window into mechanisms of habituation and drug screening
      Laura Blok (Nijmegen)

      P2.8  LTP induced increase in excitability, enhances network synchronization
      Arie Boender (Amsterdam)

      P2.9  Effects of biperiden and acute tryptophan depletion and their combination on verbal word memory and EEG: Evidence for an interaction between acetylcholine and serotonin?
      Laura Borghans (Maastricht)

      P2.10  A lesson learned from phenylketonuria mouse studies; the influence of genetic background on the behavioral phenotype
      Vibeke Bruinenberg (Groningen)

      P2.11  Role of acetylcholine and serotonin in novelty processing using an oddball paradigm
      Stéphanie Caldenhove (Maastricht)

      P2.12  The role of insular cortex in emotional memory
      Yanfen Chen (Nijmegen)

      P2.13  Functional connectivity mapping in the primary sensorimotor cortices
      Philippe Cornelisse (Utrecht)

      P2.14  Neurocognitive performance following acute mephedrone administration, with and without alcohol
      Elizabeth de Sousa Fernandes Perna (Maastricht)

      P2.15  White matter abnormalities and the effect of graded exposure in vivo in complex regional pain syndrome type I and chronic low back pain
      Mélodie Derome (Maastricht)

      P2.16  SK channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake
      Amalia Dolga (Groningen)

      P2.17  Effects of inhibition of the mammalian target of rapamycin (mTOR) pathway in the organotypic hippocampal slice culture model for temporal lobe epilepsy
      Cato Drion (Amsterdam)

      P2.18  Modulation of proteasome subunits by rapamycin and curcumin in cultured human astrocytes
      Karlijne Geijtenbeek (Amsterdam)

      P2.19  Neuropeptide Y in the lateral hypothalamus specifically increases carbohydrate intake when rats are fed a free-choice high fat high sugar diet
      Myrtille Gumbs (Amsterdam)

      P2.20  Predictors for motor learning: BDNF val66met and TMS
      Christopher Hauwert (Rotterdam)

      P2.21  Train the sedentary brain: Effects of physical inactivity in mice
      Yasmin Hulst (Groningen)

      P2.22  The effects of modafinil on motor learning in healthy male subjects
      Berna Isik (Rotterdam)

      P2.23  Long-term effects of early stress induced neuroimmune system challenges on Alzheimer’s Disease-related neuropathology
      Daniela Ivan (Amsterdam)

      P2.24  BDNF val66met polymorphism enhances eyeblink conditioning in human subjects
      Zeb Jonker (Rotterdam)

      P2.25  Resolving mechanisms of microtubule organization in dendrites of vertebrate neurons
      Olga Kahn (Utrecht)

      P2.26  Attentional biases in human perception follow predictions from neural models
      Barrie Klein (Utrecht)

      P2.27  The role of mTOR on synaptic imbalance during epileptogenesis in a mouse model for tuberous sceloris complex
      Linda Koene (Rotterdam)

      P2.28  A combination of dietary precursors and cofactors for membrane synthesis enhances neurite outgrowth in vitro
      Almar Kuipers (Utrecht)

      P2.29  Ayahuasca enhances creative divergent thinking while decreasing conventional convergent thinking
      Kim Kuypers (Maastricht)

      P2.30  Early life stress enhances Aβ-related pathology and cognitive decline in APP/PS1 mice
      Sylvie Lesuis (Amsterdam)

      P2.31  Negative involvement of NF-kB signaling in astrocytes in neurodegeneration
      Yixian Li (Groningen)

      P2.32  Role of ventral subiculum in context-induced relapse to alcohol seeking after punishment-imposed abstinence
      Nathan Marchant (Amsterdam)

      P2.33  The effects of a Western-style diet challenge on brain and metabolic functioning in early-life stress exposed mice
      Romy Meier (Amsterdam)

      P2.34  Acute purification of human adult microglia from the post-mortem brain. A systematic validation study
      Mark Mizee (Amsterdam)

      P2.35  Acute effects of oligomers of amyloid-beta on astrocyte inward rectifier channel Kir4.1 expression and function
      Laurie Mulder (Amsterdam)

      P2.36  Temporal orders in complex spike activity of Purkinje neurons during licking
      Pavithra Murugesan (Rotterdam)

      P2.37  Effects of early life stress on hippocampal cognition, neurogenesis and the immunological profile with advanced age
      Erik Nutma (Amsterdam)

      P2.38  Regulation of ROS production by voltage-gated proton channels in mouse microglia
      Yasushi Okamura (Osaka, Japan)

      P2.39  Activation of dorsal raphe serotonergic neurons promotes exploitation in a simple foraging task
      Matthijs oude Lohuis (Lisbon, Portugal)

      P2.40  Chronic high fat diet increases rapid eye movement sleep in mice
      Maria Panagiotou (Leiden)

      P2.41  The role of SK channels at the ER-mitochondria interface
      Valentina Pegoretti (Groningen)

      P2.42  Does physical activity moderate the impact of childhood trauma on the liability of mental illness?
      Lotta-Katrin Pries (Maastricht)

      P2.43  γCaMKII, a new player in the field: effect of an ID mutation in γCaMKII on neuronal morphology and migration
      Martina Proietti Onori (Rotterdam)

      P2.44  Neurogenesis is altered in the dentate gyrus of the ventral hippocampus following morphine-induced conditioned place preference
      Mina Sadighi Alvandi (Nijmegen)

      P2.45  Gene by cognition interaction on stress-induced attention for food
      Robbie Schepers (Maastricht)

      P2.46  Resistance to spike depression of a central axon terminal during in vivo high-frequency firing
      Martijn Sierksma (Rotterdam)

      P2.47  Defining the critical window of UBE3A in Angelman syndrome
      Monica Sonzogni (Rotterdam)

      P2.48  Spatial and temporal potassium clearance studied in a computational model of neurons and astrocytes
      Sjors Stouten (Amsterdam)

      P2.49  A bottom-up approach to investigate the molecular component of the neurodegenerative disorder spinocerebellar ataxia 19/22
      Claudio Tiecher (Groningen)

      P2.50  The relationship between serum IGF-1 levels and cognition in healthy adults: a meta-analysis
      Manon van Asselt (Groningen)

      P2.51  Automated classification of mice grooming behavior using JAABA software in open field and elevated plus maze
      Bastijn van den Boom (Amsterdam)

      P2.52  Light-induced locomotor response and acoustic startle response reveal differences between TLF and AB zebrafish (Danio rerio) larvae
      Ruud van den Bos (Nijmegen)

      P2.53  Probing the neurophysiological correlates of cognitive performance in rat medial prefrontal cortex
      Sven Arnold van der Burg (Amsterdam)

      P2.54  The effect of asphyxia and anesthetic choice on striatal size in near-term lambs
      Fleur van Dijck (Maastricht)

      P2.55  Considering health aspects during food choice modulates medial PFC activation in children and promotes healthier choices
      Floor van Meer (Utrecht)

      P2.56  Spontaneous activity and mitochondrial dynamics during cortical development
      Mike van Zwieten (Amsterdam)

      P2.57  The role of suboptimal mitochondrial function in stress adaptation and depression
      Elisavet Vasileiou (Nijmegen)

      P2.58  Hopping to habits: the effect of acute stress on goal-directed and habitual behaviour
      Esther Visser (Amsterdam)

      P2.59  The effect of early life stress on emotion regulation in tryptophan hydroxylase 2 deficient mice
      Magdalena Weidner (Maastricht)

      P2.60  Sensitivity and reliability of cognitive testing in adult ADHD
      Joep Wolters (Maastricht)

      P2.61  Chronic Ca2+ imaging reveals strong suppressive effects of anaesthesia on spontaneous and sound-evoked responses in dorsal inferior colliculus
      Aaron Wong (Rotterdam)

      P2.62  Differential immune priming of microglia in the white and grey matter of the aging brain
      Zhuoran Yin (Groningen)

      P2.63  Effects of dietary intervention with essential fatty acids on early-life stress induced alterations in the hippocampus throughout life
      Parand Zarekiani (Amsterdam)

      P2.64  Effects of stress hormones on dendritic protrusion densities and motility in primary hippocampal neurons
      Christiaan Zeelenberg (Amsterdam)

      P2.65  The strength of illusionary ownership over a virtual body can be modulated by affective touch
      Jutta de Jong (Utrecht)

    • Posters

      If your abstract is selected for a poster presentation, when preparing your poster please remember that the area available to you is 90 x 110 cm (width x height).

      "Portrait" is fine poster should be PORTRAIT    poster should NOT be LANDSCAPE "Landscape" not...

      Please ensure that the corresponding number is clearly indicated on the poster itself (check the poster lists). Your poster should be readable from a 2-metre distance; as a rough guideline, use a font size of 72 pts for your title, and a minimum of 28 pts for your text.

      Posters must be mounted on the day of the presentation between 08:00 and the start of the first session of the day (9:50 on Thursday, and 09:00 on Friday). Posters should only be removed at the end of the day and before 08:00 of the following day (or by 16:00 on Friday, 10 June).